Gene expression profiling in breast cancer
نویسندگان
چکیده
منابع مشابه
Gene expression profiling in breast cancer
With the advent of array-based technology and the sequencing of the human genome, comprehensive analysis of the transcriptional variation at the genomic level has become possible and the knowledge derived from gene expression profiling studies is already impressive in terms of improving our understanding of the basic biology of breast cancer. Thereby, these discoveries have also challenged the ...
متن کاملGene expression profiling in breast cancer.
PURPOSE OF REVIEW Gene expression profiling has highlighted the biologic heterogeneity of breast cancer and has begun to influence the ability of the medical community to individualize patient therapy. The review is intended to highlight the most important advances in the field over recent years with an emphasis on those most relevant to the practicing oncologist. RECENT FINDINGS Two prognost...
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Gene expression assays that are used in daily clinical practice for treating early breast cancer patients have been introduced in the clinic only recently. This review discusses the development of these arrays, summarizes the validation of those that are commercially available and indicates how the information provided by these assays can help in the care of patients. The review also provides a...
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Breast cancer is the most prevalent malignancy and the second in mortality rate cancers among all cancers in women globally. In Iran it adds up to 16 percent of all cancers and is the most prevalent cancer in Iranian women. PALB2, identified as a partner and localizer of BRCA2 and proposed to have some roles in DNA damage response, has recently been identified as a breast canc...
متن کاملGene expression profiling of circulating tumor cells in breast cancer.
BACKGROUND Determining the transcriptional profile of circulating tumor cells (CTCs) may allow the acquisition of clinically relevant information while overcoming tumor heterogeneity-related biases associated with use of tissue samples for biomarker assessment. However, such molecular characterization is challenging because CTCs are rare and outnumbered by blood cells. METHODS Here, we descri...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2006
ISSN: 0923-7534
DOI: 10.1093/annonc/mdl270